Article
APOBEC-induced mutations and their cancer effect size in head and neck squamous cell carcinoma.
Oncogene - 1 May 2019
Cannataro Vincent L, Gaffney Stephen G, Sasaki Tomoaki, Issaeva Natalia, Grewal Nicholas K S, Grandis Jennifer R, Yarbrough Wendell G, Burtness Barbara, Anderson Karen S, Townsend Jeffrey P
Abstract excerpt
Recent studies have revealed the mutational signatures underlying the somatic evolution of cancer, and the prevalences of associated somatic genetic variants. Here we estimate the intensity of positive selection that drives mutations to high frequency in tumors, yielding higher prevalences than expected on the basis of mutation and neutral drift alone. We apply this approach to a sample of 525 head and neck...
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