Article
Distinguishing cancer-associated missense mutations from common polymorphisms.
Cancer research - 15 Jan 2007
Kaminker Joshua S, Zhang Yan, Waugh Allison, Haverty Peter M, Peters Brock, Sebisanovic Dragan, Stinson Jeremy, Forrest William F, Bazan J Fernando, Seshagiri Somasekar, Zhang Zemin
Abstract excerpt
Missense variants are commonly identified in genomic sequence but only a small fraction directly contribute to oncogenesis. The ability to distinguish those missense changes that contribute to cancer progression from those that do not is a difficult problem usually only accomplished through functional in vivo analyses. Using two computational algorithms, Sorting Intolerant from Tolerant (SIFT) and the Pfam-based...
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