Article
Likelihood models of somatic mutation and codon substitution in cancer genes.
Genetics - 1 Oct 2003
Yang Ziheng, Ro Simon, Rannala Bruce
Abstract excerpt
The role of somatic mutation in cancer is well established and several genes have been identified that are frequent targets. This has enabled large-scale screening studies of the spectrum of somatic mutations in cancers of particular organs. Cancer gene mutation databases compile the results of many studies and can provide insight into the importance of specific amino acid sequences and functional domains in...
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