Article
Criticality in Tumor Evolution and Clinical Outcome
2018-05-03
Abstract excerpt
How mutation and selection determine the fitness landscape of tumors and hence clinical outcome is an open fundamental question in cancer biology, crucial for the assessment of therapeutic strategies and resistance to treatment. Here we explore the mutation-selection phase-diagram of 6721 primary tumors representing 23 cancer types, by quantifying the overall somatic point mutation load ( ML ) and selection ( dN...
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Identifiers and source
- Literature Corpus work
- 4a8b256f-8f1d-5a63-ac12-b02dc7479265
- DOI
- 10.1101/314021