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Article

Germline fitness-based scoring of cancer mutations.

Genetics - 1 Jun 2011

Fischer Andrej, Greenman Chris, Mustonen Ville

Abstract excerpt

A key goal in cancer research is to find the genomic alterations that underlie malignant cells. Genomics has proved successful in identifying somatic variants at a large scale. However, it has become evident that a typical cancer exhibits a heterogenous mutation pattern across samples. Cases where the same alteration is observed repeatedly seem to be the exception rather than the norm. Thus, pinpointing the key...

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Share to Algorithms
Share to Genetic Fitness
Share to Genome, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Germ-Line Mutation

Share to Mutation, Missense

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Share to Selection, Genetic

Share to Tumor Suppressor Proteins

Source

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Identifiers

PMID: 21441214
DOI: 10.1534/genetics.111.127480
PMCID: PMC3122307

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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