Article

Probability Distribution for Rare Neutral Mutations in Cancers and Application to Dynamic Precision Medicine of Cancer

2025-10-11

Abstract excerpt

Cancers exhibit genetic diversity between individual cancer cells. Previous work shows greater diversity than heretofore expected (1) and that also increases more quickly during a patient’s clinical course than previously thought (1, 2). Rare subclones will harbor pre-existing resistance to any single agent and may cause medium to late term relapse (1), which may evolve further variants that have simultaneous resi...

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Literature Corpus work: 9dea264a-dec3-5519-b778-bbac55ac3d35
DOI: 10.1101/2025.10.10.681641

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