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Article

18F-FDG PET imaging reveals GW4869's suppression of glioblastoma malignant progression and reversal of TMZ chemoresistance via glucose metabolic phenotype remodeling.

Journal of translational medicine - 21 Jan 2026

Han Fengfeng, Xu Yinghui, Qian Chen, Meng Baosheng, Mo Xiaofei, Chen Yuyun, Zhu Xinrui, He Chen, Zhou Mingge, Zhang Zhou

Abstract excerpt

PURPOSE: Glioblastoma (GBM) invariably develops resistance to temozolomide (TMZ), necessitating novel therapeutic strategies. This study demonstrates that inhibiting exosome secretion with GW4869 remodels the glucose metabolic phenotype to suppress malignant behavior and reverse TMZ resistance in GBM. METHODS: TMZ-resistant glioblastoma cells (U87TR) were established via concentration-gradient induction....

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Identifiers

PMID: 41566316
DOI: 10.1186/s12967-025-07668-9
PMCID: PMC12905924

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HK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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