Article
Therapeutic targeting of EGFR-activated metabolic pathways in glioblastoma.
Expert opinion on investigational drugs - 1 Aug 2013
Gao Qinglei, Lei Ting, Ye Fei
Abstract excerpt
INTRODUCTION: The highly divergent histological heterogeneities, aggressive invasion and extremely poor response to treatment make glioblastoma (GBM) one of the most lethal and difficult cancers in humans. Among key elements driving its behavior is epidermal growth factor receptor (EGFR), however, neither traditional therapy including neurosurgery, radiation, temozolomide, nor targeted EGFR therapeutics in clinic...
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