Article

LDHA-regulated tumor-macrophage symbiosis promotes glioblastoma progression

2023-10-05

Abstract excerpt

<title>Abstract</title> <p>Abundant macrophage infiltration and altered tumor metabolism are two key hallmarks of glioblastoma. By screening a cluster of metabolic small-molecule compounds, we show that inhibiting glioblastoma cell glycolysis impairs macrophage migration and lactate dehydrogenase (LDH) inhibitor stiripentol (an FDA-approved anti-seizure drug for Dravet Syndrome) emerges as the top hit. Combined p...

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Literature Corpus work: 9b0fff83-1f61-5af9-ac0b-58c564cae8c6
DOI: 10.21203/rs.3.rs-3401154/v1

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