Metabolic Imaging and Molecular Signatures Reveal Metabolic Phenotypes in Recurrent Glioblastoma.

doi:10.2967/jnumed.125.271476

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Article

Metabolic Imaging and Molecular Signatures Reveal Metabolic Phenotypes in Recurrent Glioblastoma.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 1 Jun 2026

Li Elizabeth J, Kraya Adam, Costa-Pinheiro Pedro, Scheuermann Joshua, Young Anthony J, Schubert Erin, Aboian Mariam, Doot Robert, Ware Jeffrey B, Pantel Austin R, Binder Zev A, Storm Phillip B, Resnick Adam C, Amankulor Nduka M, O'Rourke Donald M, Desai Arati, Nasrallah MacLean P, Brem Steven, Bagley Stephen J, Mankoff David, Nabavizadeh Ali

Abstract excerpt

Recurrent glioblastoma remains a clinical challenge because of metabolic heterogeneity and the difficulty in differentiating true progression from therapy-related changes. Methods: We conducted a prospective study with 30 patients, combining dynamic 18F-fluciclovine PET, perfusion MRI, and transcriptome profiling. Results: Kinetic PET parameters and MRI-derived blood volume measures correlated with overall...

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PMID: 41856669
DOI: 10.2967/jnumed.125.271476
PMCID: PMC13224916

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