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Identification of Compounds That Decrease Glioblastoma Growth and Glucose Uptake <i>in Vitro</i>

15 Jun 2018

Abstract excerpt

Tumor heterogeneity has hampered the development of novel effective therapeutic options for aggressive cancers, including the deadly primary adult brain tumor glioblastoma (GBM). Intratumoral heterogeneity is partially attributed to the tumor initiating cell (TIC) subset that contains highly tumorigenic, stem-like cells. TICs display metabolic plasticity but can have a reliance on aerobic glycolysis. Elevated...

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PMID: 29905460
DOI: 10.1021/acschembio.8b00251

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