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Article

Beyond the Warburg Effect: Oxidative and Glycolytic Phenotypes Coexist within the Metabolic Heterogeneity of Glioblastoma.

Cells - 20 Jan 2021

Duraj Tomás, García-Romero Noemí, Carrión-Navarro Josefa, Madurga Rodrigo, Mendivil Ana Ortiz de, Prat-Acin Ricardo, Garcia-Cañamaque Lina, Ayuso-Sacido Angel

Abstract excerpt

Glioblastoma (GBM) is the most aggressive primary brain tumor, with a median survival at diagnosis of 16-20 months. Metabolism represents a new attractive therapeutic target; however, due to high intratumoral heterogeneity, the application of metabolic drugs in GBM is challenging. We characterized the basal bioenergetic metabolism and antiproliferative potential of metformin (MF), dichloroacetate (DCA), sodium...

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Identifiers

PMID: 33498369
DOI: 10.3390/cells10020202
PMCID: PMC7922554

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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