Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comprehensive Analysis of Glycolytic Enzymes as Therapeutic Targets in the Treatment of Glioblastoma

1 May 2015

Abstract excerpt

Major efforts have been put in anti-angiogenic treatment for glioblastoma (GBM), an aggressive and highly vascularized brain tumor with dismal prognosis. However clinical outcome with anti-angiogenic agents has been disappointing and tumors quickly develop escape mechanisms. In preclinical GBM models we have recently shown that bevacizumab, a blocking antibody against vascular endothelial growth factor, induces...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Cancer Research and Treatments
Share to Glioma Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25932951
DOI: 10.1371/journal.pone.0123544

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comprehensive Analysis of Glycolytic Enzymes as Therapeutic Targets in the Treatment of GlioblastomaPMID 25932951Read ↗

High Expression of Glycolytic Genes in Clinical Glioblastoma Patients Correlates with Lower SurvivalSemantic proximity Read ↗

Glucose-6-phosphatase is a key metabolic regulator of glioblastoma invasion.Semantic proximity Read ↗

Studying Antitumor Effect of Sirna Gene Silencing of Hif-1α, Pfkfb4 and Pdk1 in Glioblastoma Cell LINESemantic proximity Read ↗

ALDH5A1/miR-210 axis plays a key role in reprogramming cellular metabolism and has a significant correlation with glioblastoma patient survivalSemantic proximity Read ↗

Advances in the targeting of HIF-1α and future therapeutic strategies for glioblastoma multiformeSemantic proximity Read ↗

Alpha-enolase as a potential cancer prognostic marker promotes cell growth, migration, and invasion in gliomaSemantic proximity Read ↗

A glycolysis-based ten-gene signature correlates with the clinical outcome, molecular subtype and IDH1 mutation in glioblastoma.Semantic proximity Read ↗

Hypoxia-mediated upregulation of MCT1 expression supports the glycolytic phenotype of glioblastomas.Semantic proximity Read ↗

Metabolic Rewiring in Glioblastoma Cancer: EGFR, IDH and BeyondSemantic proximity Read ↗

Effect of glycolysis inhibition by miR-448 on glioma radiosensitivitySemantic proximity Read ↗

Hexosaminidase B-driven cancer cell-macrophage co-dependency promotes glycolysis addiction and tumorigenesis in glioblastoma.Semantic proximity Read ↗

Advancing glioblastoma treatment by targeting metabolismSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.