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Article

Hexosaminidase B-driven cancer cell-macrophage co-dependency promotes glycolysis addiction and tumorigenesis in glioblastoma.

Nature communications - 1 Oct 2024

Zhu Chen, Chen Xin, Liu Tian-Qi, Cheng Lin, Cheng Wen, Cheng Peng, Wu An-Hua

Abstract excerpt

Glycolytic metabolic reprogramming in cancer is regulated by both cancer intrinsic variations like isocitrate dehydrogenase 1 (IDH1) status and non-cancerous microenvironment components like tumor associated macrophages (TAMs). However, the detailed mechanism remains elusive. Here, we identify hexosaminidase B (HEXB) as a key regulator for glycolysis in glioblastoma (GBM). HEXB intercellularly manipulates TAMs to...

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Identifiers

PMID: 39353936
DOI: 10.1038/s41467-024-52888-0
PMCID: PMC11445535

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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