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Article

Variant selection to maximize variance explained in cis-Mendelian randomization.

HGG advances - 9 Apr 2026

Zhou Ang, Karhunen Ville, Tian Haodong, Pott Janne, Patel Ashish, Slob Eric A W, Burgess Stephen

Abstract excerpt

Optimal selection of instrumental variables (IVs) from a single gene region in cis-Mendelian randomization (MR) is challenging, as variants are highly correlated due to linkage disequilibrium (LD). Using only the lead variant is convenient but may not achieve full statistical power if multiple signals exist. We compared four selection methods that incorporate correlated non-lead variants, including LD-pruning,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41548043
DOI: 10.1016/j.xhgg.2026.100573
PMCID: PMC12887808

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HP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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