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Article

Power and instrument strength requirements for Mendelian randomization studies using multiple genetic variants.

International journal of epidemiology - 1 Jun 2011

Pierce Brandon L, Ahsan Habibul, Vanderweele Tyler J

Abstract excerpt

BACKGROUND: Mendelian Randomization (MR) studies assess the causality of an exposure-disease association using genetic determinants [i.e. instrumental variables (IVs)] of the exposure. Power and IV strength requirements for MR studies using multiple genetic variants have not been explored. METHODS: We simulated cohort data sets consisting of a normally distributed disease trait, a normally distributed exposure,...

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Identifiers

PMID: 20813862
DOI: 10.1093/ije/dyq151
PMCID: PMC3147064

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