A robust cis-Mendelian randomization method with application to drug target discovery.

Abstract excerpt

Mendelian randomization (MR) uses genetic variants as instrumental variables (IVs) to investigate causal relationships between traits. Unlike conventional MR, cis-MR focuses on a single genomic region using only cis-SNPs. For example, using cis-pQTLs for a protein as exposure for a disease opens a cost-effective path for drug target discovery. However, few methods effectively handle pleiotropy and linkage...

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• Coronary Artery Disease
• Drug Discovery
• Genetic Pleiotropy
• Likelihood Functions
• Linkage Disequilibrium