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Article

A robust cis-Mendelian randomization method with application to drug target discovery.

Nature communications - 18 Jul 2024

Lin Zhaotong, Pan Wei

Abstract excerpt

Mendelian randomization (MR) uses genetic variants as instrumental variables (IVs) to investigate causal relationships between traits. Unlike conventional MR, cis-MR focuses on a single genomic region using only cis-SNPs. For example, using cis-pQTLs for a protein as exposure for a disease opens a cost-effective path for drug target discovery. However, few methods effectively handle pleiotropy and linkage...

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Source

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Identifiers

PMID: 39025905
DOI: 10.1038/s41467-024-50385-y
PMCID: PMC11258283

Genes

CAD
COLEC11
FGFR1
PCSK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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