Article

Mendelian Randomization Analysis Using Mixture Models (MRMix) for Genetic Effect-Size-Distribution Leads to Robust Estimation of Causal Effects

2018-07-13

Abstract excerpt

We propose a novel method for robust estimation of causal effects in two-sample Mendelian randomization analysis using potentially large number of genetic instruments. We consider a “working model” for bi-variate effect-size distribution across pairs of traits in the form of normal-mixtures which assumes existence of a fraction of the genetic markers that are valid instruments, i.e. they have only direct effect on...

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Literature Corpus work: 1a5797dc-1060-5d14-b6b8-c539dafa2cfc
DOI: 10.1101/367821

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