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Article

Integrating genetic data with biological insight: A practical guide to cis-Mendelian randomization.

American journal of human genetics - 7 May 2026

Karhunen Ville, Woolf Benjamin, Bhatnagar Pallav, Gill Dipender, Burgess Stephen

Abstract excerpt

Cis-Mendelian randomization is a computational approach that uses genetic variants from a biologically relevant gene region to assess the plausibility of a causal effect of a specific mechanism on an outcome of interest. As the use of cis-Mendelian randomization has recently increased due to the abundance of genetic association data for molecular quantitative traits, there is a need for informed guidance on how...

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Identifiers

PMID: 41966688
DOI: 10.1016/j.ajhg.2026.03.011
PMCID: PMC13277696

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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