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Article

Mendelian randomization with fine-mapped genetic data: Choosing from large numbers of correlated instrumental variables.

Genetic epidemiology - 1 Dec 2017

Burgess Stephen, Zuber Verena, Valdes-Marquez Elsa, Sun Benjamin B, Hopewell Jemma C

Abstract excerpt

Mendelian randomization uses genetic variants to make causal inferences about the effect of a risk factor on an outcome. With fine-mapped genetic data, there may be hundreds of genetic variants in a single gene region any of which could be used to assess this causal relationship. However, using too many genetic variants in the analysis can lead to spurious estimates and inflated Type 1 error rates. But if only a...

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Identifiers

PMID: 28944551
DOI: 10.1002/gepi.22077
PMCID: PMC5725678

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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