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Article

Conditional inference in cis-Mendelian randomization using weak genetic factors.

Biometrics - 1 Dec 2023

Patel Ashish, Gill Dipender, Newcombe Paul, Burgess Stephen

Abstract excerpt

Mendelian randomization (MR) is a widely used method to estimate the causal effect of an exposure on an outcome by using genetic variants as instrumental variables. MR analyses that use variants from only a single genetic region (cis-MR) encoding the protein target of a drug are able to provide supporting evidence for drug target validation. This paper proposes methods for cis-MR inference that use many...

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PMID: 37337418
DOI: 10.1111/biom.13888
PMCID: PMC7615409

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