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Bidirectional Mendelian Randomization and Colocalization Study of Memory B Cells and Major Depressive Disorder.

Current medical science - 1 Feb 2026

Si Shao-Meng, Xin Yue-Yang, Guan Shao-di, Dong Jie, Lu Pei, Chen Hao, Xia Wei, Xu Hui

Abstract excerpt

OBJECTIVE: Emerging evidence implicates neuroinflammation in the pathogenesis of major depressive disorder (MDD), yet the role of memory B cells remains unclear. In this study, we conducted a bidirectional two-sample Mendelian randomization (MR) study and Bayesian colocalization analyses to investigate the causal relationships between memory B-cell traits and MDD risk. METHODS: MDD summary data were gathered from...

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PMID: 41528645
DOI: 10.1007/s11596-025-00157-6

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CD27

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