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Article

Relationship between major depressive disorder and myalgic encephalomyelitis/chronic fatigue syndrome: a two-sample mendelian randomization study analysis.

Scientific reports - 7 Jan 2025

Song Wenjing, Hou Xinlei, Wu Minmin, Zhu Luwen

Abstract excerpt

Major depressive disorder (MDD) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) frequently occur together; yet their causal relationship remains unclear. To investigate the potential genetic causal link between these conditions, we conducted a two-sample Mendelian randomization (MR) analysis. Summary data from Genome-Wide Association Studies (GWAS) for MDD were sourced from the UK Biobank and the...

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PMID: 39774380
DOI: 10.1038/s41598-025-85217-6

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