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Article

Shared genetic architecture between major depressive disorder and inflammatory bowel disease: Insights from large-scale genome-wide cross-trait analysis.

Human immunology - 1 Jun 2026

Ding Yifan, Luo Qinghua, Yan Xiaojun, Deng Chenwei, Shen Pan, Xu Yueqi, Zhang Leichang

Abstract excerpt

BACKGROUND: Major depressive disorder (MDD) and inflammatory bowel disease (IBD) exhibit clinical associations, yet the cross-disease genetic links and shared mechanisms between them remain unclear. This study aims to explore the genetic associations between MDD and IBD and identify the shared risk loci, potential key tissues, and related genetic mechanisms. METHODS: Leveraging large-scale genome-wide association...

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Share to Genetic Pleiotropy
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Inflammatory Bowel Diseases

Share to Linkage Disequilibrium

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Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Source

Identifiers

PMID: 41956029
DOI: 10.1016/j.humimm.2026.111730

Genes

BSN
DAG1
DENND1B
FOXP3
MED24
NICN1
PSMD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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