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Associations between immune cells signatures and osteoarthritis: An integrated analysis of bidirectional Mendelian randomization and Bayesian colocalization.

Cytokine - 1 Jul 2024

Teng Menghao, Wang Jiachen, Su Xiaochen, Hu Jiale, Tian Ye, Zhang Yingang, Li Meng

Abstract excerpt

BACKGROUND: Previous investigations have explored the associations between immune cell signatures and osteoarthritis (OA); however, causality remains unclear. This study employs an integrated analysis, combining bidirectional Mendelian randomization (MR) and Bayesian colocalization (Coloc), to investigate causal relationships between 731 immune cells signatures and OA, identifying shared causal variants. METHODS:...

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Bayes Theorem
Genetic Predisposition to Disease
Mendelian Randomization Analysis
Monocytes
Osteoarthritis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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PMID: 38733947
DOI: 10.1016/j.cyto.2024.156633

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