Article

Mendelian randomisation and colocalisation reveal pleiotropic effects of <i>CD40/SLC12A5</i> locus on CD40 protein, depression, and immune disease

2025-08-26

Abstract excerpt

Inflammatory pathways are implicated in depression, but the specific immune proteins and causal variants involved remain unclear. This study investigated potential causal relationships between 91 immune-related plasma proteins and depression using generalized summary Mendelian randomisation. We identified a robust association between CD40 protein levels and depression (OR: 0.95, 95% CI: 0.94 - 0.97, p = 1.71 × 10⁻...

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Literature Corpus work: 2ff9247c-94dd-51c8-a13a-03a44423f35a
DOI: 10.1101/2025.08.21.25333931

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Mendelian randomisation and colocalisation reveal pleiotropic effects of <i>CD40/SLC12A5</i> locus on CD40 protein, depression, and immune diseaseDOI 10.1101/2025.08.21.25333931Read

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