Causal Associations Between Immune Cell-Specific Gene Expression and Major Depressive Disorder: A Single-Cell Transcriptome-Wide Mendelian Randomization Study.

Abstract excerpt

Major depressive disorder (MDD) is a prevalent psychiatric disorder, and its pathophysiology is related to immune dysregulation. The use of genetic evidence to identify molecular targets of specific immune cell types will provide new directions for the development of precision immunotherapy. We integrated single-cell cis-eQTL data for 14 immune cell subtypes from the OneK1K cohort with MDD GWAS summary...

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• Genome-Wide Association Study
• Major Depressive Disorder
• Mendelian Randomization Analysis
• Polymorphism, Single Nucleotide