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Article

APOE ε4 genotype, amyloid-β, and sex interact to predict tau in regions of high APOE mRNA expression.

Science translational medicine - 16 Nov 2022

Dincer Aylin, Chen Charles D, McKay Nicole S, Koenig Lauren N, McCullough Austin, Flores Shaney, Keefe Sarah J, Schultz Stephanie A, Feldman Rebecca L, Joseph-Mathurin Nelly, Hornbeck Russ C, Cruchaga Carlos, Schindler Suzanne E, Holtzman David M, Morris John C, Fagan Anne M, Benzinger Tammie L S, Gordon Brian A

Abstract excerpt

The apolipoprotein E (APOE) ε4 allele is strongly linked with cerebral β-amyloidosis, but its relationship with tauopathy is less established. We investigated the relationship between APOE ε4 carrier status, regional amyloid-β (Aβ), magnetic resonance imaging (MRI) volumetrics, tau positron emission tomography (PET), APOE messenger RNA (mRNA) expression maps, and cerebrospinal fluid phosphorylated tau (CSF...

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Identifiers

PMID: 36383681
DOI: 10.1126/scitranslmed.abl7646
PMCID: PMC9912474

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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