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Article

ApoE4 and Connectivity-Mediated Spreading of Tau Pathology at Lower Amyloid Levels.

JAMA neurology - 1 Dec 2023

Steward Anna, Biel Davina, Dewenter Anna, Roemer Sebastian, Wagner Fabian, Dehsarvi Amir, Rathore Saima, Otero Svaldi Diana, Higgins Ixavier, Brendel Matthias, Dichgans Martin, Shcherbinin Sergey, Ewers Michael, Franzmeier Nicolai

Abstract excerpt

Importance: For the Alzheimer disease (AD) therapies to effectively attenuate clinical progression, it may be critical to intervene before the onset of amyloid-associated tau spreading, which drives neurodegeneration and cognitive decline. Time points at which amyloid-associated tau spreading accelerates may depend on individual risk factors, such as apolipoprotein E ε4 (ApoE4) carriership, which is linked to...

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Share to Amyloid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37930695
DOI: 10.1001/jamaneurol.2023.4038
PMCID: PMC10628846

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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