Article

Predicting Preclinical Cognitive Decline Using Plasma P-tau217 and <i>APOE</i> Genotype in 8,582 Individuals From Different Ethnic Groups

2026-02-09

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Plasma phosphorylated tau217 (P-tau217), a plasma biomarker of Alzheimer’s disease (AD), can increase before overt symptoms. P-tau217 positivity is linked to the age at symptom onset in model-based predictions, not time to clinical event. Individuals with different genetic backgrounds, yet similar P-tau217 levels may differ in whether cognitive decline will occur or when it...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6f2beaf3-ea37-5fc9-a017-1a3ac7385dfe
DOI: 10.64898/2026.02.06.26345774

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Predicting Preclinical Cognitive Decline Using Plasma P-tau217 and <i>APOE</i> Genotype in 8,582 Individuals From Different Ethnic GroupsDOI 10.64898/2026.02.06.26345774Read

Plasma p-tau217 predicts cognitive impairments up to ten years before onset in normal older adultsSemantic proximity Read

Plasma p-tau217, p-tau181, and Aβ42 Predicts Amyloid PET Positivity in Cognitively Unimpaired AdultsSemantic proximity Read

APOE ε4 carriership status enhances age-related changes in Alzheimer’s disease plasma biomarkers concentrationsSemantic proximity Read

Association of Plasma Phosphorylated Tau 217 With Clinical Deterioration Across Alzheimer Disease StagesSemantic proximity Read

Prediction of future Alzheimer’s disease dementia using plasma phospho-tau combined with other accessible measuresSemantic proximity Read

Promising clinical tools for specific Alzheimer disease diagnosis from plasma pTau217 and ApoE genotype in a cognitive disorder unitSemantic proximity Read

CNS-selective plasma p-tau217 accurately captures Alzheimer’s disease pathology and progressionSemantic proximity Read

Clinical and demographic factors modify the association between plasma phosphorylated tau-181 and cognitionSemantic proximity Read

Scalable Markers for Early Cognitive Decline: Plasma p-tau217, Subjective Cognitive Concerns, and Digital Testing: Results from the A4/LEARN studiesSemantic proximity Read

Plasma p‐tau231 and p‐tau217 inform on tau tangles aggregation in cognitively impaired individualsSemantic proximity Read

Plasma biomarkers predict amyloid conversion and cognitive decline in cognitively unimpaired adultsSemantic proximity Read