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Article

Vasostatin-2 attenuates injury-induced neointimal hyperplasia through the ACE2/MasR/PPARγ/NR1D1/Gas1 axis.

Cardiovascular research - 22 Nov 2025

Chen Qiujing, Liu Jingmeng, Madonna Rosalinda, Li Feifei, Chen Shuai, Li Leying, Wu Xinrui, Maimati Yipaerguli, Ding Fenghua, Wang Xiaoqun, Shen Ying, Zhang Ruiyan, Shen Weifeng, Dai Yang, Lu Lin, De Caterina Raffaele

Abstract excerpt

AIMS: Vasostatin-2, a bioactive peptide derived from chromogranin A, has cardiovascular-protective and anti-inflammatory properties. However, its role in injury-induced vascular remodelling remains unclear. This study aimed to investigate whether serum vasostatin-2 levels are related to restenosis in patients following percutaneous coronary intervention (PCI), and whether this peptide influences vascular...

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Share to Angiotensin-Converting Enzyme 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41231769
DOI: 10.1093/cvr/cvaf192

Genes

ACE2
NR1D1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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