Article

Vascular Smooth Muscle–Specific NLRP3 Hyperactivation Drives Arterial Intimal Hyperplasia in Mice

2026-02-11

Abstract excerpt

<title>Abstract</title> <p> Intimal hyperplasia is a major contributor to restenosis after vascular interventions and to atherosclerotic lesion progression, driven largely by vascular smooth muscle cell (VSMC) inflammatory activation, phenotypic switching, and maladaptive remodeling. While NOD-like receptor pyrin domain 3 (NLRP3) inflammasome activity has been linked to vascular diseases, direct evidence that VS...

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Literature Corpus work: cceb3fba-6cbe-52c6-935b-1bb09c5738d3
DOI: 10.21203/rs.3.rs-8734377/v1

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