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Article

Colchicine reduces neointima formation and VSMC phenotype transition by modulating SRF-MYOCD activation and autophagy.

Acta pharmacologica Sinica - 1 Apr 2025

Zhang Bu-Chun, Zhu Wen-Ya, Wang Sheng-Nan, Zhu Meng-Meng, Ma Hui, Dong Liang, Yang Xiao-Xiao, Ma Chuan-Rui, Ma Li-Kun, Chen Yuan-Li

Abstract excerpt

Vascular smooth muscle cell (VSMC) phenotype transformation significantly contributes to vascular intimal hyperplasia. However, effective preventive and therapeutic measures are lacking. Colchicine, a binary alkaloid derived from Colchicum autumnale, is traditionally used for treating inflammatory diseases. Its role in neointima formation is not fully understood. Here, we investigated the role of colchicine in...

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Source

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Identifiers

PMID: 39663419
DOI: 10.1038/s41401-024-01438-x
PMCID: PMC11950430

Genes

MYOCD
SRF
MSX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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