Article
miRNA-34a reduces neointima formation through inhibiting smooth muscle cell proliferation and migration.
Journal of molecular and cellular cardiology - 1 Dec 2015
Chen Qishan, Yang Feng, Guo Meiqun, Wen Guanmei, Zhang Cheng, Luong Le Anh, Zhu Jianhua, Xiao Qingzhong, Zhang Li
Abstract excerpt
AIMS: We have recently reported that microRNA-34a (miR-34a) regulates vascular smooth muscle cell (VSMC) differentiation from stem cells in vitro and in vivo. However, little is known about the functional involvements of miR-34a in VSMC functions and vessel injury-induced neointima formation. In the current study, we aimed to establish the causal role of miR-34a and its target genes in VSMC proliferation,...
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