Article

Integrative multiomics analysis of neointima proliferation in human saphenous vein: implications for bypass graft disease

2023-11-16

Abstract excerpt

<h4>Introduction</h4> Human saphenous veins (SV) are widely used as grafts in coronary artery bypass (CABG) surgery but often fail due to neointima proliferation (NP). NP involves complex interplay between vascular smooth muscle cells (VSMC) and fibroblasts. Little is known, however, regarding the transcriptomic and proteomic dynamics of NP. Here, we performed multi-omics analysis in an ex vivo tissue culture mo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 38fda1d9-7931-5fbd-84b8-09d1f63b6af1
DOI: 10.1101/2023.11.14.567053

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrative multiomics analysis of neointima proliferation in human saphenous vein: implications for bypass graft diseaseDOI 10.1101/2023.11.14.567053Read

Human Saphenous Vein Ex Vivo Culture as a Translational Model of Intimal HyperplasiaSemantic proximity Read

Integrated single-nuclei and spatial transcriptomic analysis reveals propagation of early acute vein harvest and distension injury signaling pathways following arterial implantationSemantic proximity Read

Graft-Induced Reprogramming Under Arterial Hemodynamic Stress is Associated with a Shared Proteomic Phenotype in Arterial and Venous Conduits Following Coronary Artery Bypass GraftingSemantic proximity Read

Spatial Transcriptomics Reveals Region-Specific Remodeling in Vein Grafts After Peripheral Arterial BypassSemantic proximity Read

Integrative Multi-omics Approach Reveals the Molecular Characterization and Differences of ECM-PI3K-Akt Pathway among Coronary Artery Bypass Grafting Conduits with Clinical ImplicationsSemantic proximity Read

Transcriptomic and Multi-scale Network Analyses Reveal Key Drivers of Cardiovascular DiseaseSemantic proximity Read

The intricate cellular ecosystem of human peripheral veins as revealed by single-cell transcriptomic analysis.Semantic proximity Read

How vascular smooth muscle cell phenotype switching contributes to vascular disease.Semantic proximity Read

Antiatherosclerotic Phenotype of Perivascular Adipose Tissue Surrounding the Saphenous Vein in Coronary Artery Bypass Grafting.Semantic proximity Read

Single-cell transcriptomics reveals skewed cellular communication and phenotypic shift in pulmonary artery remodelingSemantic proximity Read

Identification of cellular heterogeneity and key signaling pathways associated with vascular remodeling and calcification in young and old primate aortas based on single-cell analysisSemantic proximity Read