Article
Association of Serum HMGB2 Levels With In-Stent Restenosis: HMGB2 Promotes Neointimal Hyperplasia in Mice With Femoral Artery Injury and Proliferation and Migration of VSMCs.
Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2017
He Yu Hu, Wang Xiao Qun, Zhang Jian, Liu Zhu Hui, Pan Wen Qi, Shen Ying, Zhu Zheng Bin, Wang Ling Jie, Yan Xiao Xiang, Yang Ke, Zhang Rui Yan, Shen Wei Feng, Ding Feng Hua, Lu Lin
Abstract excerpt
OBJECTIVE: In a previous study, we established diabetic and nondiabetic minipig models with coronary artery in-stent restenosis (ISR). Mass spectrometry showed that high-mobility group box (HMGB) 2 level was higher in ISR than in non-ISR tissue from diabetic minipigs. We here investigated whether serum HMGB2 levels were related to ISR in coronary artery disease patients. The effect of HMGB2 was evaluated in mice...
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