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Article

MIA SH3 Domain ER Export Factor 3 Deficiency Prevents Neointimal Formation by Restoring BAT-Like PVAT and Decreasing VSMC Proliferation and Migration.

Frontiers in endocrinology - 1 Jan 2021

Lei Yu, Xu Jianfei, Li Mengju, Meng Ting, Chen Meihua, Yang Yongfeng, Li Hongda, Zhuang Tao, Zuo Junli

Abstract excerpt

Abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) and excessive accumulation of dysfunctional PVAT are hallmarks of pathogenesis after angioplasty. Recent genome-wide association studies reveal that single-nucleotide polymorphism (SNP) in MIA3 is associated with atherosclerosis-relevant VSMC phenotypes. However, the role of MIA3 in the vascular remodeling response to injury remains...

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Adipose Tissue, Brown
Aryl Hydrocarbon Receptor Nuclear Translocator
Cell Movement
Cell Proliferation
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Muscle, Smooth, Vascular

Myocytes, Smooth Muscle

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Open in PubMed Open full text

Identifiers

PMID: 34858331
DOI: 10.3389/fendo.2021.748216
PMCID: PMC8631732

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