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Article

NCOR1 maintains the homeostasis of vascular smooth muscle cells and protects against aortic aneurysm.

Cell death and differentiation - 1 Mar 2023

Du Lin-Juan, Sun Jian-Yong, Zhang Wu-Chang, Liu Yuan, Liu Yan, Lin Wen-Zhen, Liu Ting, Zhu Hong, Wang Yong-Li, Shao Shuai, Zhou Lu-Jun, Chen Bo-Yan, Lu Hongjian, Li Ruo-Gu, Jia Feng, Duan Sheng-Zhong

Abstract excerpt

Phenotypic modulation of vascular smooth muscle cells (VSMCs) plays critical roles in the pathogenesis of aortic aneurysm (AA). The function of nuclear receptor corepressor1 (NCOR1) in regulation of VSMC phenotype and AA is unclear. Herein, using smooth muscle NCOR1 knockout mice, we demonstrated that smooth muscle NCOR1 deficiency decreased both mRNA and protein levels of contractile genes, impaired stress...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36151473
DOI: 10.1038/s41418-022-01065-1
PMCID: PMC9984378

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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