Article
Mindin regulates vascular smooth muscle cell phenotype and prevents neointima formation.
Clinical science (London, England : 1979) - 1 Jul 2015
Zhu Li-Hua, Huang Ling, Zhang Xiaojing, Zhang Peng, Zhang Shu-Min, Guan Hongjing, Zhang Yan, Zhu Xue-Yong, Tian Song, Deng Keqiong, Li Hongliang
Abstract excerpt
Mindin/spondin 2, an extracellular matrix (ECM) component that belongs to the thrombospondin type 1 (TSR) class of molecules, plays prominent roles in the regulation of inflammatory responses, angiogenesis and metabolic disorders. Our most recent studies indicated that mindin is largely involved in the initiation and development of cardiac and cerebrovascular diseases [Zhu et al. (2014) J. Hepatol. 60, 1046-1054;...
Topics
- Animals
- Carotid Artery Injuries
- Cell Differentiation
- Cell Movement
- Cell Proliferation
- Cells, Cultured
- Disease Models, Animal
- Extracellular Matrix Proteins
- Gene Expression Regulation
- Genotype