Article

PCSK9 promotes vascular neointimal hyperplasia through non-lipid regulation of vascular smooth muscle cell proliferation, migration, and autophagy

2024-04-29

Abstract excerpt

<title>Abstract</title> <p>We aim to explore the impact of Proprotein convertase subtilisin-kexin type 9 (PCSK9) and its inhibitor evolocumab on neointimal hyperplasia. Wild type and PCSK9 knockout (PCSK9-/-) mice were subjected to ligation of the common carotid artery, with or without subcutaneous injection of PCSK9i Evolocumab. Mouse aortic vascular smooth muscle (MOVAS) cells were pretreated with evolocumab or...

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Literature Corpus work: 455cd34b-af8b-5ed7-aa8c-b07eb9271f63
DOI: 10.21203/rs.3.rs-4278817/v1

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