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Article

Polygenic prediction of coronary heart disease among 130 000 Mexican adults.

European journal of preventive cardiology - 18 Feb 2026

Liu Tianshu, Berumen Jaime, Torres Jason, Alegre-Díaz Jesus, Baca Paulina, González-Carballo Carlos, Ramirez-Reyes Raul, Rivas Fernando, Aguilar-Ramirez Diego, Bragg Fiona, Herrington William, Hill Michael, Trichia Eirini, Vergara-Lope Alejandra, Wade Rachel, Collins Rory, Kuri-Morales Pablo, Emberson Jonathan R, Tapia-Conyer Roberto, Gnatiuc Friedrichs Louisa

Abstract excerpt

AIMS: Most polygenic risk scores (PRSs) for coronary heart disease (CHD) are derived from European ancestry populations. This paper evaluates the performance of CHD PRSs in a Mexican population. METHODS AND RESULTS: 133 207 participants aged 35-79 years from the Mexico City Prospective Study were included. Eight PRSs (comprising 44-6 472 620 polymorphisms) were selected for prediction of CHD (defined as...

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PMID: 41231729
DOI: 10.1093/eurjpc/zwaf728
PMCID: PMC7618473

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