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Differential performance of polygenic risk scores for heart disease in Hispanic/Latino subgroups: Findings of the Hispanic Community Health Study/Study of Latinos.

HGG advances - 9 Oct 2025

Hutten Christina G, Boehm Frederick J, Smith Jennifer A, Spitzer Brian W, Wassertheil-Smoller Sylvia, Isasi Carmen R, Cai Jianwen, Unkart Jonathan T, Sun Jiehuan, Persky Victoria, Daviglus Martha L, Sofer Tamar, Argos Maria

Abstract excerpt

Coronary heart disease (CHD) is a leading cause of death among Hispanics/Latinos in the United States (US) whose underrepresentation in genomic research may worsen health disparities. We evaluated predictive performance of polygenic risk scores (PRSs) for myocardial infarction (MI) using data from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), a cohort of 16,415 participants from 4 US centers....

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Identifiers

PMID: 40734275
DOI: 10.1016/j.xhgg.2025.100486
PMCID: PMC12391791

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