Article
Clinical Utility of Multimarker Genetic Risk Scores for Prediction of Incident Coronary Heart Disease: A Cohort Study Among Over 51 000 Individuals of European Ancestry.
Circulation. Cardiovascular genetics - 1 Dec 2016
Iribarren Carlos, Lu Meng, Jorgenson Eric, Martínez Manuel, Lluis-Ganella Carla, Subirana Isaac, Salas Eduardo, Elosua Roberto
Abstract excerpt
BACKGROUND: We evaluated whether including multilocus genetic risk scores (GRSs) into the Framingham Risk Equation improves the predictive capacity, discrimination, and reclassification of asymptomatic individuals with respect to coronary heart disease (CHD) risk. METHODS AND RESULTS: We performed a cohort study among 51 954 European-ancestry members of a Northern California integrated healthcare system (67%...
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