Article

Shared genetic effects on chromatin and gene expression reveal widespread enhancer priming in immune response

2017-01-26

Abstract excerpt

Noncoding regulatory variants are often highly context-specific, modulating gene expression in a small subset of possible cellular states. Although these genetic effects are likely to play important roles in disease, the molecular mechanisms underlying context-specificity are not well understood. Here, we identify shared quantitative trait loci (QTLs) for chromatin accessibility and gene expression (eQTLs) and sho...

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Literature Corpus work: 0fe0d81f-cc6e-523b-b2cf-d01b333304b6
DOI: 10.1101/102392

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