Article
Identification of somatic mutations in postmortem human brains by whole genome sequencing and their implications for psychiatric disorders.
Psychiatry and clinical neurosciences - 1 Apr 2018
Nishioka Masaki, Bundo Miki, Ueda Junko, Katsuoka Fumiki, Sato Yukuto, Kuroki Yoko, Ishii Takao, Ukai Wataru, Murayama Shigeo, Hashimoto Eri, Nagasaki Masao, Yasuda Jun, Kasai Kiyoto, Kato Tadafumi, Iwamoto Kazuya
Abstract excerpt
AIM: Somatic mutations in the human brain are hypothesized to contribute to the functional diversity of brain cells as well as the pathophysiology of neuropsychiatric diseases. However, there are still few reports on somatic mutations in non-neoplastic human brain tissues. This study attempted to unveil the landscape of somatic mutations in the human brain. METHODS: We explored the landscape of somatic mutations...
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