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Article

Genome-wide association study and HLA genotyping for beryllium disease susceptibility in a European descent population.

Gene - 5 Nov 2025

Liao Shu-Yi, Fingerlin Tasha E, Jacobson Sean, Mroz Margaret M, Rosenman Kenneth D, Rossman Milton D, Virji MAbbas, McCanlies Erin C, Schuler Christine R, Yucesoy Berran, Glessner Joseph, Duke Jamie L, Hakonarson Hakon, Monos Dimitri S, Maier Lisa A

Abstract excerpt

BACKGROUND: Workplace exposure to beryllium can result in beryllium sensitization (BeS), a cell-mediated immune response that can progress to chronic beryllium disease (CBD), a granulomatous lung disease. DPB1-E69 is highly associated with CBD and BeS, although DRB1-E71 may also be a risk factor in the absence of DPB1-E69. OBJECTIVE: This study 1) identified novel genetic variants associated with CBD/BeS using a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41075949
DOI: 10.1016/j.gene.2025.149820
PMCID: PMC12732325

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