Article
HLA-DPB1 and chronic beryllium disease: a HuGE review.
American journal of epidemiology - 1 Mar 2003
McCanlies Erin C, Kreiss Kathleen, Andrew Michael, Weston Ainsley
Abstract excerpt
The human leukocyte antigen (HLA) complex is a series of genes located on chromosome 6 that are important in normal immune function. Susceptibility to chronic beryllium disease, a granulomatous lung disease that appears in workers exposed to beryllium, is modified by genetic variants of the HLA-DP subregion. Evaluation of HLA-DPB1 sequence motifs in current and former beryllium workers implicated a glutamic acid...
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