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Human Leukocyte Antigen Class II Amino Acid Epitopes: Susceptibility and Progression Markers for Beryllium Hypersensitivity

1 Mar 2002

Abstract excerpt

Chronic beryllium disease (CBD) is a hypersensitivity granulomatosis characterized by beryllium hypersensitivity (BH) and mediated by CD4+ T cells. However, all individuals with BH may not develop CBD. To examine the role of the three different human leukocyte antigen (HLA) Class II isotypes in BH with (CBD) and without clinical disease (BHWCD), we performed DNA-based typing of HLA-DPB1, HLA-DQB1, and HLA-DRB1...

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PMID: 11897645
DOI: 10.1164/ajrccm.165.6.2104002

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