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Article

Chronic beryllium disease, HLA-DPB1, and the DP peptide binding groove.

Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 2012

Silveira Lori J, McCanlies Erin C, Fingerlin Tasha E, Van Dyke Michael V, Mroz Margaret M, Strand Matthew, Fontenot Andrew P, Bowerman Natalie, Dabelea Dana M, Schuler Christine R, Weston Ainsley, Maier Lisa A

Abstract excerpt

Multiple epidemiologic studies demonstrate associations between chronic beryllium disease (CBD), beryllium sensitization (BeS), and HLA-DPB1 alleles with a glutamic acid residue at position 69 (E69). Results suggest that the less-frequent E69 variants (non-*0201/*0202 alleles) might be associated with greater risk of CBD. In this study, we sought to define specific E69-carrying alleles and their amino acid...

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Identifiers

PMID: 22972925
DOI: 10.4049/jimmunol.1200798
PMCID: PMC4347851

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