Article
HLA-DPB1 glutamate 69: a genetic marker of beryllium disease.
Science (New York, N.Y.) - 8 Oct 1993
Richeldi L, Sorrentino R, Saltini C
Abstract excerpt
Chronic beryllium disease (CBD) is a lung disorder related to beryllium exposure and is characterized by the accumulation in the lung of beryllium-specific CD4+ major histocompatibility complex (MHC) class II-restricted T lymphocytes. Evaluation of MHC class II genes in 33 CBD cases and 44 contro...
Topics
- Adult
- Alleles
- Amino Acid Sequence
- Base Sequence
- Berylliosis
- Beryllium
- Disease Susceptibility
- Female
- Genes, MHC Class II
- Genotype
- Glutamates
- Glutamic Acid
- HLA-DP Antigens
- Humans
- Linkage Disequilibrium
- Male
- Middle Aged
- Molecular Sequence Data